Roles and mechanisms of neutrophils in disease pathogenesis of osteoarthritis

doi:10.3877/cma.j.issn.1674-134X.2026.01.009

Abstract

Abstract:

Osteoarthritis is a common joint disease characterized by cartilage damage and chronic inflammation, significantly affecting the quality of life of patients. Recent studies suggest that neutrophils, as important immune cells, play a critical role in the pathogenesis of osteoarthritis. Neutrophils are involved not only in inflammatory responses but may also influence the cartilage repair process. However, current research on the role of neutrophils in osteoarthritis still requires further investigation. This review aimed to summarize the role of neutrophils in osteoarthritis and its underlying mechanisms, and assess the therapeutic potential of targeting neutrophils, providing new insights and directions for future research and treatment.

Key words: Neutrophils, Osteoarthritis, Cellular microenvironment, Cartilage diseases, Inflammation

Tianyou Ma, Mo Wu, Xuefei Zhao, Shuaijie Lyu, Peijian Tong. Roles and mechanisms of neutrophils in disease pathogenesis of osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2026, 20(01): 69-76.

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References 74

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