Progress of bone marrow mesenchymal stem cells in pathogenesis of hormonal femoral head necrosis

doi:10.3877/cma.j.issn.1674-134X.2025.04.008

Abstract

Abstract:

Steroids induced avascular necrosis of femoral head (SANFH) is a metabolic disease in which ischaemia and necrosis of the femoral head occur as a result of obstruction of local blood circulation due to continuous administration of high doses of glucocorticoids (GCs). SANFH has a high disability rate, which seriously affects the quality of patients’ survival, but its specific pathogenesis has not been fully elucidated, among which the imbalance of osteogenic and lipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is considered to be one of the main mechanisms for the development of SANFH. The research progresses of BMSCs in the pathogenesis of SANFH were reviewed to provide a reference basis for further prevention and treatment of SANFH.

Key words: Mesenchymal stem cells, Glucocorticoids, Femoral head necrosis, Osteoblasts

Zhiqiang Lin, Jiahuan Li, Kai Zhang, Wenshuai Li, Jian Liu, Zequn Deng, Yongjie Qiao, Shenghu Zhou. Progress of bone marrow mesenchymal stem cells in pathogenesis of hormonal femoral head necrosis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(04): 464-471.

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References 68

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