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Chinese Journal of Joint Surgery(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (02): 207-213. doi: 10.3877/ cma.j.issn.1674-134X.2025.02.011

• REVIEWS • Previous Articles    

Research progress of chondrocyte copper death in osteoarthritis

Bo Chen1, Xiangyi Li2,()   

  1. 1. Changzhi Medical College, Changzhi 046000, China
    2. the Second People’s Hospital of Changzhi, Changzhi 046000, China
  • Received:2024-09-10 Online:2025-04-01 Published:2025-06-17
  • Contact: Xiangyi Li

Abstract:

Cuproptosis is a novel form of cell death, in which excessive intracellular copper induces the aggregation of lipoylated dihydrolipoic acid-acetyl transferase(DLAT)associated with the mitochondrial tricarboxylic acid (tCA) cycle, resulting in proteotoxic stress. It plays a crucial role in the death of chondrocytes in osteoarthritis, and this view has been confirmed in relevant studies. Research on the mechanism of chondrocyte cuproptosis has revealed that there are four key nodes in cuproptosis. Cuproptosis is closely related to copper accumulation within chondrocytes and changes in mitochondrial function, and is regulated by relevant genes and the immune system. Studies on the intervention of chondrocyte cuproptosis have found that copperrelated compounds, HPP@Cu gel, and the interference of endoplasmic reticulum stress are all targeted therapies for cuproptosis in osteoarthritis.

Key words: Osteoarthritis, Copper, Cell death, Chondrocytes

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