Application of matrix metalloproteinase responsive hydrogel in osteoarthritis

doi:10.3877/ cma.j.issn.1674-134X.2025.01.011

Abstract

Abstract:

Osteoarthritis is a chronic disease characterized by degenerative changes in articular cartilage and osteophyte formation at the joint margins.Its pathogenesis is complex and intricate.Under physiological conditions, the activity of matrix metalloproteinases (MMPs) is strictly regulated.However, in the pathological state of osteoarthritis, the expression and activity of MMPs are abnormally elevated, becoming a key factor in the degradation of articular cartilage.Therefore, treatment strategies targeting MMPs are particularly important in the treatment of osteoarthritis.In recent years, hydrogels and nano platforms as responsive materials of MMPs have shown great potential in the field of osteoarthritis treatment.Therefore, this article aimed to summarize and discuss the application of both in the treatment of osteoarthritis, and evaluate their potential as novel therapeutic tools.

Key words: Osteoarthritis, Matrix metalloproteinases, Hydrogel, Nanoparticle drug delivery system

Xiyu Wang, Junjie Zhao, Pengfei Huang, Zhaokun Zhang, YuHao Zhao, Haiyan Zhao. Application of matrix metalloproteinase responsive hydrogel in osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(01): 76-81.

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