Research advances in correlation between pyroptosis and rheumatoid arthritis

doi:10.3877/cma.j.issn.1674-134X.2022.05.009

Abstract

Abstract:

Pyroptosis is a newly discovered and confirmed the pattern of programmed cell death associated with inflammation, which is strongly associated with the development of a variety of diseases. As a common inflammatory autoimmune disease, the pathogenesis of rheumatoid arthritis (RA) has not been fully understood. Previous studies have shown that the process of pyroptosis plays an important role in the pathogenesis of RA. This review aimed to provide a new theoretical basis for elucidating the pathogenesis of RA, improving the treatment and prognosis by summarizing the important pathways involved in the process of pyroptosis and the studies between the molecules and RA.

Key words: Pyroptosis, Arthritis, rheumatoid, NF-kappa B, Inflammasomes

Yao Ma, Mingyi Yang, Ke Xu, Bo Hao, Peng Xu. Research advances in correlation between pyroptosis and rheumatoid arthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2022, 16(05): 586-591.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhgjwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-134X.2022.05.009

https://zhgjwkzz.cma-cmc.com.cn/EN/Y2022/V16/I05/586

References 35

[1]	黄清宇，杜楚江，张雨竹，等．细胞焦亡研究进展[J]．中国免疫学杂志，2020，36(2):245-250.
[2]	Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death[J]. Trends Biochem Sci, 2017, 42(4): 245-254.
[3]	Green DR. The coming decade of cell death research: five riddles[J]. Cell, 2019, 177(5): 1094-1107.
[4]	Zhang YY, Chen X, Gueydan C, et al. Plasma membrane changes during programmed cell deaths[J]. Cell Res, 2018, 28(1): 9-21.
[5]	Yi YS. Role of inflammasomes in inflammatory autoimmune rheumatic diseases[J]. Korean J Physiol Pharmacol, 2018, 22(1): 1-15.
[6]	Guo C, Fu R, Wang S, et al. NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis[J]. Clin Exp Immunol, 2018, 194(2): 231-243.
[7]	Rathinam VK, Zhao Y, Shao F. Innate immunity to intracellular LPS[J]. Nat Immunol, 2019, 20(5): 527-533.
[8]	Feng SY, Fox D, Man SM. Mechanisms of gasdermin family members in inflammasome signaling and cell death[J]. J Mol Biol, 2018, 430(18): 3068-3080.
[9]	Evavold CL, Kagan JC. Defying death: The (W)hole truth about the fate of GSDMD pores[J]. Immunity, 2019, 50(1): 15-17.
[10]	Tang L, Lu C, Zheng G, et al. Emerging insights on the role of gasdermins in infection and inflammatory diseases[J/OL]. Clin Transl Immunol, 2020, 9(10): e1186. DOI: 10.1002/cti2.1186.
[11]	Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death[J]. Trends Biochem Sci，2017，42(4): 245-254.
[12]	Yang DH, He Y, Munoz-Planillo R, et al. Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock[J]. Immunity, 2015, 43(5): 923-932.
[13]	Sarhan J, Liu BC, Muendlein HI, et al. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during yersinia infection[J]. Proc Natl Acad Sci USA, 2018, 115(46): E10888-E10897.
[14]	Zhao J, Jiang P, Guo S, et al. Apoptosis, autophagy, netosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis[J/OL]. Front Immunol, 2021, 12: 809806. DOI: 10.3389/fimmu.2021.809806.
[15]	Chadha S, Behl T, Bungau S, et al. Mechanistic insights into the role of pyroptosis in rheumatoid arthritis[J]. Curr Res Transl Med, 2020, 68(4): 151-158.
[16]	Jimi E, Fei H, Nakatomi C. NF-κB signaling regulates physiological and pathological chondrogenesis[J/OL]. Int J Mol Sci, 2019, 20(24): 6275. DOI: 10.3390/ijms20246275.
[17]	Xia ZB, Meng FR, Fang YX, et al. Inhibition of NF-κB signaling pathway induces apoptosis and suppresses proliferation and angiogenesis of human fibroblast-like synovial cells in rheumatoid arthritis[J/OL]. Medicine, 2018, 97(23): e10920. DOI: 10.1097/MD.0000000000010920.
[18]	Jimi E, Takakura N, Hiura F, et al. The role of NF-κB in physiological bone development and inflammatory bone diseases: is NF-κB inhibition "killing two birds with one stone" ？[J/OL]. Cells, 2019, 8(12): 1636. DOI: 10.3390/cells8121636.
[19]	Li G, Xia Z, Liu Y, et al. SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway[J/OL]. Biosci Rep, 2018, 38(3): BSR20180541. DOI: 10.1042/BSR20180541.
[20]	Spel L, Martinon F. Inflammasomes contributing to inflammation in arthritis[J]. Immunol Rev, 2020, 294(1): 48-62.
[21]	Yang P, Feng W, Li C, et al. LPS induces fibroblast-like synoviocytes RSC-364 cells to pyroptosis through NF-κB mediated dual signalling pathway[J]. J Mol Histol, 2021, 52(4): 661-669.
[22]	Ling Y, Xiao M, Huang Z-W, et al. Jinwujiangu capsule treats fibroblast-like synoviocytes of rheumatoid arthritis by inhibiting pyroptosis via the NLRP3/CAPSES/GSDMD pathway[J/OL]. Evid Based Compl Alt, 2021, 2021: 4836992. DOI: 10.1155/2021/4836992.
[23]	杨盼盼. LPS介导NF-κB信号通路触发滑膜成纤维细胞焦亡//中华口腔医学会口腔生物医学专业委员会.2019第九次全国口腔生物医学学术年会论文汇编，遵义市，2019：152.
[24]	赵紫琴，徐瑾，王瑞琳，等. 类风湿性关节炎滑膜组织中NLRP3炎性小体及下游因子IL-1β/IL-18的表达及意义 [J]. 临床与实验病理学杂志，2019，35(5):534-538.
[25]	Addobbati C, Da Cruz H, Adelino JE, et al. Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients[J]. Inflamm Res, 2018, 67(3): 255-264.
[26]	Wu XY, Li KT, Yang HX, et al. Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis[J/OL]. J Autoimmun, 2020, 106: 102336. DOI: 10.1016/j.jaut.2019.102336.
[27]	Ramosguzman CA, Zinovjev K, Tunon I. Modeling caspase-1 inhibition: implications for catalytic mechanism and drug design [J]. Eur J Med Chem, 2019, 169: 159-167.
[28]	Bambouskova M, Potuckova L, Paulenda T, et al. Itaconate confers tolerance to late NLRP3 inflammasome activation[J/OL]. Cell Rep, 2021, 34(10): 108756. DOI: 10.1016/j.celrep.2021.108756.
[29]	Choudhary N, Bhatt LK, Prabhavalkar KS. Experimental animal models for rheumatoid arthritis[J]. Immunopharmacol Immunotoxicol, 2018, 40(3): 193-200.
[30]	吴小山．酸敏感离子通道1a在佐剂性关节炎大鼠关节软骨细胞焦亡中的作用及其机制研究[D]．合肥：安徽医科大学，2017.
[31]	Wu X, Ren G, Zhou R, et al. The role of Ca(2+) in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis[J]. Lab Invest, 2019, 99(4): 499-513.
[32]	Li XF, Shen WW, Sun YY, et al. MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes[J]. Joint Bone Spine, 2016, 83(6): 695-700.
[33]	Shin TH, Kim HS, Kang TW, et al. Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis[J/OL]. Cell Death Dis, 2016, 7(12): e2524. DOI: 10.1038/cddis.2016.442.
[34]	He T, Xu X, Zhang XY, et al. Effectiveness of Huai Qi huang granules on juvenile collagen-induced arthritis and its influence on pyroptosis pathway in synovial tissue[J]. Curr Med Sci, 2019, 39(5): 784-793.
[35]	Nozaki Y, J RI, Sakai K, et al. Inhibition of the IL-18 receptor signaling pathway ameliorates disease in a murine model of rheumatoid arthritis[J/OL]. Cells, 2019, 9(1): 11. DOI: 10.3390/cells9010011.

Please choose a citation manager

Content to export