To observe the analgesia effects of femoral nerve block(FNB)combined with periarticular injection(PAI) in early postoperation after total knee replacement (TKA), and analyze its clinical application value and prospect.

A total of 126 patients(126 knees) were retrospectively included in this study according to inclusion criteria and exclusion criteria, who accepted TKA from October, 2018 to February, 2019.The patients were divided into the experimental group who accepted FNB+ PAI(n=63) and the control group who accepted FNB+ ACB(n=63). All the surgeries were completed by one experienced doctor. The results of visual analogue score(VAS), opioid consumption(using t test), the incidence of nausea and vomiting, and the knee range of motion(ROM) were compared between the two groups before and at six, 12, 24, 48 and 72 h after surgery(using chi-square test).

There was no statistical difference between the two groups on preoperative demographic characteristics and preoperative VSA score (P>0.05). VAS scores in the experimental group were lower than those in the control group at six, 12, 24 h after surgery(t=3.232, 2.946, 3.146, P<0.05), and had no statistical difference at 48, 72 h after surgery(t=0.527, 1.108, P>0.05). The knee ROM in experimental group was better than that in control group at 24 h after surgery(t=3.082, P<0.05), and had no difference at 48, 72 h after surgery(t=0.543, 0.902, P>0.05). The opioids consumption(t=0.857, P>0.05), the incidence of nausea and vomiting (χ²=52.29, P>0.05) were the same in both groups. None of the patients occurred quadriceps weakness, nor the local hematoma complications.

When compared with FNB+ ACB, FNB+ PAI is an effective method in early postoperative analgesia therapy after TKA, with better pain and wide ROM at 24 h after surgery, which can be an alternative method for FNB+ ACB.