The balance of bone remodeling is regulated by direct contact between osteoblasts and osteoclasts, which also determines the indivisibility of the two. Recent studies have shown that erythropoietin producing hepatomocellular receptor interacting protein (Ephrin) ligand B2 in pre-osteoclasts and erythropoietin-producing hepatocyte(Eph)receptor B4 on the membrane of osteoblasts regulate bone homeostasis through direct contact, thereby activating downstream signaling pathways. Forward signaling: the activation of downstream signaling molecules Ras homolog gene family member A (Rho A) activity by the activation of Eph receptors on the surface of osteoblast membranes promotes the differentiation and maturation of pre-osteoclasts. Reverse signaling: the activation of EphrinB2 ligands plays a reverse role in inhibiting the osteoclast differentiation by inhibiting the C-fos/NFATc1 transcriptional cascade of osteoclast-related transcription factors. Osteolysis caused by wear particles can significantly increase the expression of ephrinB2 ligand on osteoclasts, and wear particles can promote high expression of NFATc1. However, bidirectional signaling pathway can be used to reduce or even inhibit the further differentiation of osteoclasts caused by wear particles.