Role of fibroblast-like synoviocytes in pathogenesis of rheumatoid arthritis

doi:10.3877/cma.j.issn.1674-134X.2024.02.010

Abstract

Abstract:

Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic, symmetrical, polyarthritis of the synovium as the main clinical manifestation, and its pathogenesis is not fully understood. In recent years, with the continuous exploration of RA cells and molecular biological mechanisms, many studies have focused on fibroblast-like synoviocytes (FLSs), which play a crucial role in the development of RA through the secretion of various inflammatory factors. As a result, there has been a shift in the treatment of RA from traditional non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and disease-modifying anti-rheumatic drugs (DMARDs) to biologically targeted drugs that target cytokines, but these drugs inevitably produce corresponding side effects, so there is an urgent need for new, safe and effective treatments to alleviate the suffering of RA patients. This review overviewed the effects of RA-FLSs on RA in terms of inflammation, autophagy and apoptosis, aiming to provide help for the subsequent basic research and clinical work.

Key words: Arthritis, rheumatoid, Synoviocytes, Inflammation, Autophagy, Apoptosis, Therapeutics

Fan Wang, Hui Yu, Jiale Xie, Huanhuan Xu, Rui Ma, Aihaiti Yirixiati·, Ke Xu, Peng Xu. Role of fibroblast-like synoviocytes in pathogenesis of rheumatoid arthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(02): 225-230.

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