Research progress on etiology of patellofemoral arthritis based on proinflammatory cytokines

doi:10.3877/cma.j.issn.1674-134X.2023.01.010

Abstract

Abstract:

With an aging society and changes in lifestyles, the incidence of patellofemoral arthritis is currently increasing. Most of the knee arthritis is considered as a lesion between the patella and the femur. This article reviewed the previous literatures on the pathogenesis of patellofemoral arthritis, focused on the related pathological changes from the level of cytokines and discussed prostaglandin E2(PGE2), interleukin(IL)-1β, IL-6, tumor necrosis factor(TNF)-α, matrix metalloproteinases (MMPs) and other related inflammatory factors that associate with the etiology and pathogenesis of patellofemoral arthritis. It may provide theoretical directions in diagnosis and treatment of patellofemoral arthritis as well as for further research.

Key words: Osteoarthritis, Knee, Cytokines

Yujie Wang, Yuting Fang, Xuan Zhang, Wuping Yao, Zhi Liu. Research progress on etiology of patellofemoral arthritis based on proinflammatory cytokines[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(01): 71-76.

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URL: https://zhgjwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-134X.2023.01.010

https://zhgjwkzz.cma-cmc.com.cn/EN/Y2023/V17/I01/71

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