Research progress of mechanical sensitive ion channel in spinal degenerative diseases

doi:10.3877/cma.j.issn.1674-134X.2022.06.015

Abstract

Abstract:

Intervertebral disc degeneration and spinal facet joint arthritis are comman spinal degenerative diseases. It is important causes of chronic low back pain and intermittent acute attacks. It is a degenerative change induced by multiple factors including mechanics, genetics and biology, which is manifested in the destruction of the structure and function of intervertebral discs and facet joints. Mechanical sensitive ion channel protein Piezo1 is considered as the key factor of intervertebral disc degeneration and facet joint osteoarthritis under mechanical environment. Piezo1 is abnormally activated in degenerative intervertebral disc tissue and joint tissue, and deeply participates in the pathogenesis of intervertebral disc degeneration and osteoarthritis. Therefore, this article made a review from the perspective of Piezo1 on intervertebral disc degeneration and osteoarthritis, in order to understand its mechanism on intervertebral disc degeneration and facet joint disorder, provide direction for future research, and provide a therapeutic targets for those diseases.

Key words: Intervertebral disc degeneration, Zygapophyseal joint, Low back pain

Yutao Wang, Jiaxin Chen, Shenyi Lu, Yiqi Huang, Weizheng Guo, Jianlang Liang, Zhaoke Huang, Qi Liu. Research progress of mechanical sensitive ion channel in spinal degenerative diseases[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2022, 16(06): 756-761.

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