To investigate the effect of total knee arthroplasty in the patients with rheumatoid arthritis.

A total of 79 patients with rheumatoid arthritis treated in Guidong People's Hospital of Guangxi Zhuang Autonomous Regionl between January 2017 and March 2019 were selectedas the research objects, and they were divided into the study group (n=40) and the control group (n=39) using a random number table method. The control group were treated with hydroxychloroquine sulfate tablets, and the study group were treated with total knee arthroplasty on the basis of the control group. Both the two groups were treated for four weeks. The knee joint function, quality of life, the levels of serum cytokine before and after four weeks of treatment were analyzed and compared by t test, the incidence of complications during treatment and the study group coronal and sagittal deformities of the posterior knee after treatment in the two groups were analyed and compared by chi-square test.

Compared with before treatment, after four weeks of treatment, the score of american hospital for special surgery (HSS), joint mobility and the score of various dimensions of quality of life of the two groups increased, the study group was higher than the control group (t=7.222, 2.226, 16.611, 13.035, 14.563, 4.344, all P<0.05); while the levels of serum rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) of the two groups decreased, the study group was lower than the control group (t=33.330, 3.578, 2.819, all P<0.05). After four weeks of treatment, the rates of coronal and sagittal deformities of the knee joint in the study group were lower than before treatment (22.5% vs 52.5%, 20.0% vs 50.0%; χ²=7.680, 7.912, P<0.05). The incidence of complications between the two groups during treatment showed no statistically significant difference (5.0% vs 10.3%, χ²=0.777, P>0.05).

Total knee arthroplasty for rheumatoid arthritis could significantly reduce the levels of serum RF, CRP, and ESR in patients, and could increase the scores of HSS in patientsand joint mobility, thereby promoting the recovery of knee function and improving the quality of life of patients, and with high security.