To explore the effect of rinsing and disinfecting with iodophor on the thyroid function of patients who recievestotal total hip arthroplasty(THA).

From January 2017 to September 2017, 50 patients (without thyroid disease and infection) who were scheduled to undergo THA in joint surgery department of Shanghai Changhai Hospital were randomly divided into two groups: experimental group (25 patients were treated with iodophor irrigation and immersion disinfection for five minutes after implantation of prosthesis) and control group (25 patients were treated with saline irrigation and immersion for five minutes). The same rehabilitation training program was used in both groups after operation. The results of thgroid stimulating hormone (TSH), tree tri-iodothyronine (FT₃), tetra-iodothyronine (FT₄) and urine iodine were collected before operation, at the postoperative one day, the one week and one month. The changes of TSH, FT₃, FT₄ and urine iodine were evaluated before the operation and postoperative one day, one week and one month. The differences among groups at different time points were tested by paired sample t test.

All the 50 patients completed the operation successfully and were followed up for at least one month after the operation. The preoperative FT₃ of the experimental group was (4.4±0.8) pmol/L, and at postoperative one day, one week, one month were (1.7±0.3), (4.7±0.7)and(4.3±1.0)pmol/L respectively; the preoperative FT₃ of the control group was(4.2±0.7) pmol/L, and were (2.9±0.5), (3.8±0.8), (4.5±0.9) pmol/L respectively at postoperative one day, one week and one month. The experimental group preoperative FT₄ was (15.4±3.6) pmol/L, and were (10.7±2.5), (12.1±2.7), (15.3±3.5) pmol/L respectively at postoperative one day, one weeks and one months; the control group preoperative FT₄ was (15.1±3.8), and were (13.9±2.7), (14.6±2.3), (15.3±3.1)pmol/L respectively at postoperative one day, one week, one month. The experimental group preoperative TSH was (2.6±1.3) mIU/L, and at postoperative one day, one week and one month were (1.3±0.3), (3.1±1.0), (2.4±1.9) mIU/L respectively; the control group preoperative TSH was (2.6±1.0) mIU/L, and at postoperative after one day, one week, one month were (1.3±0.3), (2.0±1.1), (2.5±1.5) mIU/L respectively. The experimental group of preoperative urinary iodine was (251±97) μg/L, and at postoperative one day, one week and one month were (919±224), (453±106), (253±112) μg/L respectively; the control group preoperative one was(254±98) μg/L, and at postoperative one day, one week and one month were (262±215), (255±107), (244±94) μg/L respectively. There were significant differences in TSH, FT₃, FT₄ and urinary iodine between the two groups at one day(TSH: t=0.648, FT₃: t=7.165, FT₄: t=3.296, urinary iodine value: t=8.184; all P<0.05) and one week after operation(TSH: t=2.691, FT₃: t=3.339, FT₄: t=2.754, urinary iodine: t=5.092; all P<0.05). There was no significant difference in TSH, FT₃, FT₄ and urinary iodine values in one month after the operation (all P>0.05).

The use of iodophor irrigation during THA surgery may present a transient effect on thyroid function, which shows the greatest influence on the first day after the operation, but one month later the influence disappear.