Numerous guidelines have been developed aiming to optimize the controversial treatments of knee osteoarthritis (KOA) by using intra-articular injection. However, different pieces of evidence lead to a different level of recommendations, some of them even mutual contradiction, which confused most of the clinical workers. Besides, the big clinical data from China about intra-articular injection is lacking, which prevents the establishment of clinical practice guidelines of our own. As the connection with international orthopedics, the domestic scholars are paying attention to the establishment of a real clinical practice guideline. They are working hard and performing expert consensus to call for basic and clinic researches with higher levels of evidence, to better serve the clinic and patients.