Research progression of alpha-2-macroglobulin in post-traumatic osteoarthritis and relataed diseases

doi:10.3877/cma.j.issn.1674-134X.2018.04.016

Abstract

Abstract:

The growing population of post-traumatic osteoarthritis(PTOA) patients have brought great burden to both the patients themselves and the society. However, with the discover of alpha-2-macroglobulin(α2M), a broad spectrum of protease inhibitors, the greater protective effect has been found on post-traumatic osteoarthritis and relataed diseases. This article reviewed the structure and fuction of α2M, the main effect on early diagnosis and treatment of PTOA, the promotion during the repair of anterior cruciate ligament injury, the protective effects on meniscus injury and the positive effects on tendon-bone healing during anadesma reconstruction. This article also pointed out some of the major challenges including specific mechanisms of action and biosecurity of α2M, which need some in-depth studies in the future.

Key words: alpha-Macroglobulin, Wounds and injuries, Osteoarthritis, Ddiagnosis, Therapeutics

Ruipeng Zhao, Shaowei Wang, Pengcui Li, Gang Li, Chunli Wang, Yu Zhao, Zhiwei Zhang, Xiaochun Wei. Research progression of alpha-2-macroglobulin in post-traumatic osteoarthritis and relataed diseases[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2018, 12(04): 539-543.

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URL: https://zhgjwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-134X.2018.04.016

https://zhgjwkzz.cma-cmc.com.cn/EN/Y2018/V12/I04/539

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