Advances in mechanism of macrophage polarization in periprosthetic osteolysis

doi:10.3877/ cma.j.issn.1674-134X.2024.05.009

Abstract

Abstract:

Artificial joint replacement is one of the effective treatments for osteoarthropathy. Although the postoperative effect of this treatment is satisfactory， periprosthesis osteolysis is still an important factor leading to the failure of joint replacement. Among them， macrophage polarization is the most important factor to induce osteolysis around the prosthesis. Therefore， it is a better choice to regulate the polarization of macrophages by non-surgical treatment， thus preventing osteolysis and treating bone lesions. The main metabolic patterns of macrophage polarization， the relationship between inflammation and osteoclast/osteoblast，and the potential signaling pathways are described for the first time. The relationship between the mechanism of macrophage polarization and periprosthesis osteolysis as well as the therapeutic measures were described. The effect of macrophage polarization in the periprosthesis micro-environment affects the long-term applicability of the prosthesis. Therefore， immunomodulation can be used as an intervention to prolong the use of prostheses，and metabolic reprogramming can be regarded as an emerging potential target.

Key words: Macrophage, Macrophage activation, Signal transduction, Osteolysis, Energy metabolism

Kai Zhang, Yongjie Qiao, Zhiqiang Lin, Jian Liu, Zequn Deng, Fei Tan, Jiankang Zeng, Jiahuan Li, Peijie Li, Shenghu Zhou. Advances in mechanism of macrophage polarization in periprosthetic osteolysis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2024, 18(05): 618-625.

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References 57

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特征	M1型巨噬细胞	M2型巨噬细胞
刺激因子	干扰素、脂多糖、肿瘤坏死因子等	转化生长因子、白细胞介素4和白细胞介素13等
表达因子	肿瘤坏死因子α、白细胞介素1β、白细胞介素6、活性氧等	白细胞介素10和白细胞介素-1受体拮抗剂、转化生长因子-β、基质金属蛋白酶1和12
亚型		M2a、M2b、M2c、M2d
亚型鉴别	αCD86、诱导型一氧化氮合成酶	αCD163、Toll样受体2、NCK相关蛋白1L、Fcγ受体IIa、细胞色素b-245α链、整合素亚基β2、精氨酸酶-1
主要功能	吞噬清除病原体，抗原，坏死衰老细胞及细胞碎片等，参与抗原提呈	抗炎，防止组织过度损伤，加快组织修复与再生

特征	M1型巨噬细胞	M2型巨噬细胞
刺激因子	干扰素、脂多糖、肿瘤坏死因子等	转化生长因子、白细胞介素4和白细胞介素13等
表达因子	肿瘤坏死因子α、白细胞介素1β、白细胞介素6、活性氧等	白细胞介素10和白细胞介素-1受体拮抗剂、转化生长因子-β、基质金属蛋白酶1和12
亚型		M2a、M2b、M2c、M2d
亚型鉴别	αCD86、诱导型一氧化氮合成酶	αCD163、Toll样受体2、NCK相关蛋白1L、Fcγ受体IIa、细胞色素b-245α链、整合素亚基β2、精氨酸酶-1
主要功能	吞噬清除病原体，抗原，坏死衰老细胞及细胞碎片等，参与抗原提呈	抗炎，防止组织过度损伤，加快组织修复与再生

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